Novel fiber laser systems have been developed by an international team of researchers to provide efficient detection of cancerous cells during the surgical process. The fiber laser is a part of a compact multimodal imaging system that enables testing tissue samples directly during surgery.
It should be noted that usually microscopes based on fiber laser technology apply only one imaging technique (confocal microscopy, multiphoton microscopy, or Anti-Stokes Raman Spectroscopy). Nevertheless, their combination in a single fiber laser system provides faster and robust information about tissues and possible diseases.
Even though these techniques can lead to making excitation laser systems complex, large, and expensive, this research is very promising. The team plans to produce a fiber laser that emits several excitation wavelengths and various laser beam pulse durations. Such a fiber laser technology allows combining several techniques in one compact device.
To be more precise, the fiber laser system helps to test tissue samples directly after surgery or even during it resulting in more precise detection of tumor margins. “Combining three methods allows superimposing several levels of information and thus obtaining a more precise picture of the cells.”
These fiber lasers provide a simpler way to distinguish cancerous cells from healthy ones. Now researchers are developing an ultrashort laser beam pulse source for the new laser system. It should be noted that this source will synchronously pump two optical parametric oscillators.
It is planned that the fiber laser system will emit several laser beam outputs with tunable wavelengths. Herewith, these laser beam pulses are generated in both the femtosecond and picosecond range. The fiber laser technology is considered to be very promising for the three imaging techniques in a multimodal system.
Moreover, it is required to produce a quick electronic system to monitor the fiber laser in the multimodal system. Herewith, the laser system will operate with the microscope’s scanner technology. Such a benefit of a novel fiber laser system as favorable thermal properties removes the need for additional air-cooling.
Advantages of fiber laser technology make the imaging system less expensive, more energy-efficient, and smaller than traditional microscopes with titanium-sapphire laser systems. The potential applications of novel fiber laser systems include the detection of drugs and nanoparticles in tissues and cells or testing of the effectiveness of cosmetic products.
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