Modern laser systems in microscopy allow researchers to discover how molecules within a cell react and interact when it comes to investigating how tumors grow. Such laser beam microscopy requires to be labeled with fluorescent substances that make them visible to researchers, however, this action can misrepresent the molecule behavior. New microscopes based on fiber laser technology operates without the necessity to label the molecules.
A team of researchers from Germany and China has designed the microscope that includes a unique compact fiber laser instead of the solid-state laser systems that had previously been applied. To be more precise, the microscope based on fiber laser technology produces less noise than conventional designs, allowing them to be used in operating rooms. The fiber laser system provides label-free microscopic imaging that is considered to be a popular topic in current biomedical research.
It should be noted that usually staining with fluorescent markers can not be performed at in-vivo tissues, herewith, label-free microscopy plays a crucial role in understanding how different new types of cells develop from stem cells as well as in differentiation a tumor from normal tissue without staining. Fiber lasers allow researchers to operate without markers in the muscle tissue cells of the heart and liver, as well as other cells.
Advanced fiber laser systems find their wide application in optical nanomicroscopes, in which laser beam light is transmitted through glass fibers rather than through a solid body of crystal or glass. Nevertheless, previously solid-state laser systems surpassed fiber lasers because of their higher power and less noise. Researchers used two synchronized optical resonators (laser beam cavities), wavelengths of which were required to hit the specimen through the lens at exactly the same time resulting in challenging control of the whole process.
The developed fiber laser microscope presents an essential benefit that includes easier operation than a conventional solid-state laser system. Additionally, such a fiber laser system is less subjected to error, the process becomes faster because it does not need to label the molecules. Herewith, the prototype of the fiber laser microscope promotes the development of portable devices that can be applied in the operating room, for example, to mark tumor borders during an operation.
The new fiber laser technology provides benefits for numerous biomedical applications, and the early detection of tumors is only one specific example of this. Moreover, it is planned to employ the new fiber laser microscope in clinical applications in the nearest future, because preliminary studies have been already conducted and demonstrated amazing results.
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